Using the antidepressant Paxil late in pregnancy seems to be associated with a higher rate of complications in the newborn, but the findings do not mean women should not take the drug.
In a new study, Paxil did not increase the risk of birth defects when taken during any trimester. However, 12 infants born to 55 women who took the drug late in pregnancy had complications that required prolonged hospitalization. Nine of the babies had respiratory distress, two had hypoglycemia (abnormally low blood sugar) and one had jaundice -- a yellowing of the skin due to reduced liver function.
Paxil is a newer type of antidepressant known as a selective serotonin-reuptake inhibitor (SSRI), and is known to cause a "discontinuation" syndrome in adults -- a type of withdrawal. There had been case reports of a similar syndrome in infants born to mothers who have taken the drug during pregnancy.
Motherisk counsels physicians and women about the safety of medications during pregnancy, largely based on a huge database of its own safety studies. Read more...
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